Konstantin severinov biography of william
Konstantin severinov biography of william murphy.
Research Overview
Transcription is the central step, and a major regulatory checkpoint of gene expression.
Konstantin severinov biography of william
Defective transcription regulation is the common cause of aberrant growth and development and may result in malignant transformation. Transcription is carried out by DNA-dependent RNA polymerases–large, multisubunit molecular machines.
Understanding RNA polymerase (RNAP) structure and function is a key to understanding gene expression in molecular detail. The long-term objective of our research is to uncover the molecular basis of transcription mechanism and regulation through structure-functional analysis of bacterial RNAP and associated proteins.
In addition, we use bacteriophage development as a model system to study temporal regulation of gene expression and to uncover novel mechanisms of transcription regulation. We also study microcins, small ribosomally-synthesized inhibitors of bacterial growth.
The following research projects were actively pursued during the last